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Dejerine in 1892 described specific symptoms resulting from a lesion to the corpus callosum that caused alexia without agraphia. The patient had a lesion in the left occipital lobe, blocking sight in the right visual field , and in the splenium of the corpus callosum. Dejerine interpreted this case as a disconnection of the speech area in the ...
The end part of the corpus callosum, towards the cerebellum, is called the splenium. This is the thickest part, and overlaps the tela choroidea of the third ventricle and the midbrain, and ends in a thick, convex, free border. Splenium translates as "bandage" in Greek. The trunk of the corpus callosum lies between the splenium and the genu.
It is secondary association cortex, making connections with numerous other brain regions. The region's name refers to its anatomical location immediately behind the splenium of the corpus callosum in primates, although in rodents it is located more
Split-brain or callosal syndrome is a type of disconnection syndrome when the corpus callosum connecting the two hemispheres of the brain is severed to some degree. It is an association of symptoms produced by disruption of, or interference with, the connection between the hemispheres of the brain.
The corpus callosum is essential to the communication between the two hemispheres. [2] A recent study of individuals with agenesis of the corpus callosum suggests that the corpus callosum plays a vital role in problem solving strategies, verbal processing speed, and executive performance. Specifically, the absence of a fully developed corpus ...
Other studies have built on this to imply that the anterior commissure can be a compensatory pathway in those without a corpus callosum, presenting diffusion tensor imaging (DTI) techniques to better elucidate the anterior commissure and how it might be implicated in various functions (Winter & Franz, 2014). [2]
They run backward parallel with one another, between the layers of the tela chorioidea of the third ventricle, and beneath the splenium of the corpus callosum, where they unite to form a short trunk, the great cerebral vein of Galen; just before their union each receives the corresponding basal vein.
Pure alexia almost always involves an infarct to the left posterior cerebral artery (which perfuses the splenium of the corpus callosum and left visual cortex, among other things). The resulting deficit will be pure alexia – i.e., the patient can write but cannot read (even what they have just written).