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Benfotiamine has been studied in laboratory models of diabetic retinopathy, neuropathy, and nephropathy. [10] A 2021 review of its use for diabetic polyneuropathy described two clinical trials which showed improvements in neuropathic pain and neuropathic symptoms scores, the latter of which showed a dose-response effect. [4]
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Dextromethorphan is an NMDA antagonist at high doses. ... Benfotiamine is an oral prodrug of Vitamin B1 that has several placebo-controlled double-blind trials ...
As with many supplements, there is a possible risk of mild side effects, especially in high doses. These include stomach upset, headache, or skin flushing. NAD injections may cause temporary ...
As of October 2018, this study published in 2016 is still the most recent human study about taking oral Benfotiamine for a long time. 300mg/day benfotiamine given to Alzheimer patients for 18 months. No other doses were tested so it is impossible to know the optimal dose yet. Impressive benefits, but only 5 humans participated in the study!
A Western diet is often high in omega-6 fatty acids, experts say, due to widely available seed oils often used to fry fast foods and manufacture the ultraprocessed foods that now make up about 70% ...
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