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Norethisterone acetate (NETA), also known as norethindrone acetate and sold under the brand name Primolut-Nor among others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders.
Side effects of norethisterone include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth. [ 16 ] [ 17 ] Norethisterone is a progestin, or a synthetic progestogen , and hence is an agonist of the progesterone receptor , the biological target of progestogens like progesterone .
Estradiol is an estrogen, or an agonist of the estrogen receptors, whereas norethisterone acetate is a progestin (synthetic progestogen), or an agonist of the progesterone receptors. [14] Relugolix suppresses ovarian sex hormone production , whereas estradiol and norethisterone acetate provide hormonal add-back to reduce hypogonadal and ...
The use of COCP is dependent on desirable effects and risk of adverse events with progestin component and dose of estrogen and progestin component. Estrogen component: Estradiol, Ethinylestradiol, or Estetrol; First-generation progestin: Norethindrone acetate, Ethynodiol diacetate, Lynestrenol, Norethynodrel
Additionally, many medications – both prescribed and over-the-counter - have common side effects, such as lightheadedness or confusion, that can lead to falls, so it is important for people to ...
NETE is a prodrug of norethisterone in the body. [13] Upon reaching circulation, it is rapidly converted into norethisterone by esterases.Hence, as a prodrug of norethisterone, NETE has essentially the same effects as norethisterone, acting as a potent progestogen with additional weak androgenic and estrogenic activity (the latter via its metabolite ethinylestradiol). [14]
Fibroids are benign (non-cancerous) muscle tumors of the uterus that can cause heavy menstrual bleeding, pain, bowel or bladder problems and infertility. [2] Some women may not experience any symptoms, but many do, including heavy bleeding with periods. [2]
Side effects of progestogens include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and changes in liver protein production among others. [1] [2] Other side effects of progestogens may include an increased risk of breast cancer, cardiovascular disease, and blood clots. [2]