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Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
12156 Ensembl ENSG00000125845 ENSMUSG00000027358 UniProt P12643 P21274 RefSeq (mRNA) NM_001200 NM_007553 RefSeq (protein) NP_001191 NP_031579 Location (UCSC) Chr 20: 6.77 – 6.78 Mb Chr 2: 133.39 – 133.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. Function BMP-2 like other bone morphogenetic ...
Both type 1 and 2 bone morphogenetic protein receptors have a single transmembrane segment. Additionally, both types have a cysteine-rich extracellular domain and a cytoplasmic serine threonine kinase domain. [3]
655 12162 Ensembl ENSG00000101144 ENSMUSG00000008999 UniProt P18075 P23359 RefSeq (mRNA) NM_001719 NM_007557 RefSeq (protein) NP_001710 NP_001710.1 NP_031583 Location (UCSC) Chr 20: 57.17 – 57.27 Mb Chr 2: 172.71 – 172.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is ...
651 110075 Ensembl ENSG00000152785 ENSMUSG00000029335 UniProt P12645 Q8BHE5 RefSeq (mRNA) NM_001201 NM_173404 NM_001310677 RefSeq (protein) NP_001192 NP_001297606 NP_775580 Location (UCSC) Chr 4: 81.03 – 81.06 Mb Chr 5: 99 – 99.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the ...
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Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. [4] [5] BMP4 is found on chromosome 14q22-q23.BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily.