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[4] [5] Complications are related to persistent vomiting and dehydration which may lead to kidney failure and electrolyte problems. [2] Weekly cannabis use is generally required for the syndrome to occur; synthetic cannabinoids can also cause CHS. [6] [5] The underlying mechanism is unclear, with several possibilities proposed.
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
Cannabis is the most widely used illicit drug in the Western world. [3] In the United States, 10-20% of those who begin the use of cannabis daily will later become dependent. [4] [5] Cannabis use can lead to addiction, which is defined as "when the person cannot stop using the drug even though it interferes with many aspects of his or her life."
The symptoms of liver disease that may appear, though, include nausea, lack of appetite, discomfort on the right upper corner of the abdomen, generalized itching, dark urine and yellow ...
Dr. Peter Grinspoon, one of the leading cannabis researchers in the U.S., said that while it’s important to note the two studies do not directly prove marijuana causes heart problems, it’s an ...
Next, 11-OH-THC is metabolized in the liver into 11-COOH-THC, which is the second metabolic product of THC. [66] 11-COOH-THC is not psychoactive. [64] Ingestion of edible cannabis products lead to a slower onset of effect than the inhalation of it because the THC travels to the liver first through the blood before it travels to the rest of the ...
Cannabis intoxication limits vary by state — anywhere from zero to 5 nanograms per milliliter of blood. But most clinical researchers say those numbers don’t correlate with impairment.
Some is also stored in fat in addition to being metabolized in the liver. Δ 9-THC is metabolized to 11-hydroxy-Δ 9-THC, which is then metabolized to 9-carboxy-THC. [49] Some cannabis metabolites can be detected in the body several weeks after administration.