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Cold agglutinins, or cold autoantibodies, occur naturally in nearly all individuals. These natural cold autoantibodies occur at low titers, less than 1:64 measured at 4 °C, and have no activity at higher temperatures. Pathologic cold agglutinins occur at titers over 1:1000 and react at 28-31 °C and sometimes at 37 °C.
Cold sensitivity or cold intolerance is unusual discomfort felt by some people when in a cool environment. [ 1 ] Cold sensitivity may be a symptom of hypothyroidism , anemia , low body weight, iron deficiency , vitamin B 12 deficiency , fevers , fibromyalgia or vasoconstriction . [ 2 ]
The ROMs of the game and its sequel were formerly offered by the owner Randel Reiss for free download. In 2021, however, the rights to both games were purchased by Piko Interactive, leding the download links for the ROMs to disappear from Technopop's website [121], but they are still available for free download on Zophar's Domain.
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Date free Free type Metacritic ; Barkley, Shut Up and Jam: Gaiden: Tales of Game's Studios Tales of Game's Studios RPG: Microsoft Windows, macOS: January 22, 2008 Freeware [9] 93 [10] The Battle for Wesnoth: David White and others David White and others Turn-based strategy: Microsoft Windows, macOS, Linux: October 2005 October 2005 Freeware [11 ...
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Signs of folate deficiency anemia most of the time are subtle. [4] Anemia (macrocytic, megaloblastic anemia) can be a sign of advanced folate deficiency in adults. [1] Folate deficiency anemia may result in feeling tired, weakness, changes to the color of the skin or hair, open sores on the mouth, shortness of breath, palpitations, lightheadedness, cold hands and feet, headaches, easy bleeding ...