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Dicloxacillin is a narrow-spectrum β-lactam antibiotic of the penicillin class. [1] It is used to treat infections caused by susceptible (non-resistant) Gram-positive bacteria . [ 1 ] It is active against beta-lactamase -producing organisms such as Staphylococcus aureus , which would otherwise be resistant to most penicillins .
Dicloxacillin: Dynapen (discontinued) Flucloxacillin: Floxapen (Sold to European generics Actavis Group) Mezlocillin: Mezlin (discontinued) Methicillin: Staphcillin (discontinued) Nafcillin: Unipen (discontinued) Oxacillin: Prostaphlin (discontinued) Penicillin G: Pentids (discontinued) Penicillin V: Veetids (Pen-Vee-K) (discontinued) Piperacillin
Flucloxacillin has similar pharmacokinetics, antibacterial activity, and indications to dicloxacillin, and the two agents are considered interchangeable. It is reported to have higher, though rare, incidence of severe hepatic adverse effects than dicloxacillin, [28] but a lower incidence of renal adverse effects. [23]
Cloxacillin is an antibiotic useful for the treatment of several bacterial infections. [1] This includes impetigo, cellulitis, pneumonia, septic arthritis, and otitis externa. [1]
Oxacillin is a penicillinase-resistant β-lactam.It is similar to methicillin, and has replaced methicillin in clinical use.Other related compounds are nafcillin, cloxacillin, dicloxacillin, and flucloxacillin.
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Penicillin resistance in Staphylococcus aureus [3] appeared very soon after penicillin entered general clinical use in 1943, and the mechanism of resistance was the production of β-lactamase.
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