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Chlordiazepoxide can cause physical dependence and what is known as the benzodiazepine withdrawal syndrome. Withdrawal from chlordiazepoxide or other benzodiazepines often leads to withdrawal symptoms that are similar to those seen with alcohol and barbiturates. The higher the dose and the longer the drug is taken, the greater the risk of ...
The molecular structure of chlordiazepoxide, the first benzodiazepine, marketed by Hoffmann–La Roche beginning in 1960 and branded as Librium. The first benzodiazepine, chlordiazepoxide (Librium), was synthesized in 1955 by Leo Sternbach while working at Hoffmann–La Roche on the development of tranquilizers. The pharmacological properties ...
Long-acting benzodiazepines with long-acting active metabolites, such as diazepam and chlordiazepoxide, are often prescribed for benzodiazepine or alcohol withdrawal as well as for anxiety if constant dose levels are required throughout the day.
Librium (chlordiazepoxide) – a benzodiazepine used to treat acute alcohol withdrawal; Lithobid, Eskalith – a mood stabilizer; Loxam (escitalopram) – an antidepressant of the SSRI class; Lunesta (eszopiclone) – a non-benzodiazepine hypnotic; Luvox (fluvoxamine) – an antidepressant of the SSRI class
Chlordiazepoxide is an anti-anxiety medication belonging to the benzodiazepine class. [4] Its use in IBS is thought to be due to its calming ability for patients that have IBS symptoms that are worsened by anxiety. Clidinium bromide is a synthetic quaternary ammonium antimuscarinic, [5] a sub-class of a family of drugs known as anticholinergics.
A physical dependence develops more quickly with higher potency benzodiazepines such as alprazolam (Xanax) than with lower potency benzodiazepines such as chlordiazepoxide (Librium). [10] Symptom severity is worse with the use of high doses, or with benzodiazepines of high potency or short half-life.
Researchers have found that the far more common overdose risk with Suboxone occurs when an addict shoots up the drug intravenously in combination with a respiratory depressant, such as a benzodiazepine like Xanax. The Times article did not question the efficacy of Suboxone when used properly.
Chlordiazepoxide (Librium) is the benzodiazepine of choice in uncomplicated alcohol withdrawal due to its long half-life. [ 12 ] Lorazepam or diazepam is available as an injection for patients who cannot safely take medications by mouth.