Ad
related to: loael threshold 2
Search results
Results from the WOW.Com Content Network
The increase in dose above threshold dose induces an increase in the percentage of biological responses. [2] Several benchmarks have been established to describe the effects of a particular dose of drug in a particular species, such as NOEL(no-observed-effect-level), NOAEL (no-observed-adverse-effect-level) and LOAEL (lowest-observed-adverse ...
The lowest-observed-adverse-effect level (LOAEL), or the lowest-observed-adverse-effect concentration (LOAEC), is the lowest concentration or amount of a substance found by experiment or observation that causes an adverse alteration of morphology, function, capacity, growth, development, or lifespan of a target organism distinguished from normal organisms of the same species under defined ...
[2] In toxicology it is specifically the highest tested dose or concentration of a substance (i.e. a drug or chemical) or agent (e.g. radiation), at which no such adverse effect is found in exposed test organisms where higher doses or concentrations resulted in an adverse effect. [3] [4] [5]
This level was thus identified at the lowest observed adverse effect level (LOAEL). A NOAEL of 0.5 mg/kg was estimated by dividing the LOAEL by a three-fold uncertainty factor. The NOAEL was then divided by the standard 10-fold inter- and 10-fold intraspecies uncertainty factors to arrive at the RfD of 0.005 mg/kg/day.
A threshold model or linear no-threshold model may be more appropriate, depending on the circumstances. A recent critique of these models as they apply to endocrine disruptors argues for a substantial revision of testing and toxicological models at low doses because of observed non- monotonicity , i.e. U-shaped dose/response curves.
Straalen N.M. (1997) – How to measure no effect II: Threshold effects in ecotoxicology. Environmetrics, 8: 249 – 253. Crane M. and Newman M.C. (2000) – What level of effect is a no observed effect? Environmental Toxicology and Chemistry, vol 19, no 2, 516 – 519
Threshold limit value (TLV ... (0.03–0.1 mg/kg in 2 of 24 ... "The LOAEL in reproduction studies with nivalenol given by oral exposure was stated to be 1.4 ...
Lowest-observed-adverse-effect level; Reference dose – Maximum acceptable oral dose of a toxic substance in the US; Exposure action value – A limit set on occupational exposure to noise where, when those values are exceeded, employers must take steps to monitor the exposure levels.
Ad
related to: loael threshold 2