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Intravenous Ascorbic Acid or PAA, pharmacologic ascorbic acid [1] (also known as vitamin C or L-ascorbic acid), is a process that delivers soluble ascorbic acid directly into the bloodstream. It is not approved for use to treat any medical condition.
Vitamin C dietary supplements are available as tablets, capsules, drink mix packets, in multi-vitamin/mineral formulations, in antioxidant formulations, and as crystalline powder. [40] Vitamin C is also added to some fruit juices and juice drinks. Tablet and capsule content ranges from 25 mg to 1500 mg per serving.
About 70–90% of vitamin C is absorbed by the body when taken orally at normal levels (30–180 mg daily). Only about 50% is absorbed from daily doses of 1 gram (1,000 mg). Even oral administration of megadoses of 3g every four hours cannot raise blood concentration above 220 micromol/L. [19]
Vitamin D overdose is impossible from UV exposure; the skin reaches an equilibrium where the vitamin degrades as fast as it is created. [ 42 ] Cholecalciferol can be produced in skin from the light emitted by the UV lamps in tanning beds , which produce ultraviolet primarily in the UVA spectrum, but typically produce 4% to 10% of the total UV ...
Vitamin D compounds, specifically cholecalciferol (D3) and ergocalciferol (D2), are used in rodenticides due to their ability to induce hypercalcemia, a condition characterized by elevated calcium levels in the blood. This overdose leads to organ failure and is pharmacologically similar to vitamin D's toxic effects in humans.
Calcifediol is the precursor for calcitriol, the active form of vitamin D. [3] [4] It is synthesized in the liver, by hydroxylation of cholecalciferol (vitamin D 3) at the 25-position. [3] This enzymatic 25-hydroxylase reaction is mostly due to the actions of CYP2R1 , present in microsomes , although other enzymes such as mitochondrial CYP27A1 ...
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