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The cell survival curve is a curve often used in radiobiology that represents the relationship between the amount of cells retaining reproductive capabilities and the absorbed dose of radiation from said cells.
The OER is reduced for low doses as evaluated for cultured mammalian cells exposed to x-rays under aerobic (21% O2, 159 mmHg) and anoxic (nitrogen) conditions. [17] Typical fractionation treatments are daily 2 Gy exposures, as below this dose the so-called 'shoulder' or repair region of the cell survival curve is encroached upon reducing the ...
The Gompertz curve or Gompertz function is a type of mathematical model for a time series, named after Benjamin Gompertz (1779–1865). It is a sigmoid function which describes growth as being slowest at the start and end of a given time period.
Survival analysis is a branch of statistics for analyzing the expected duration of time until one event occurs, such as death in biological organisms and failure in mechanical systems.
The survival function is also known as the survivor function [2] or reliability function. [3] The term reliability function is common in engineering while the term survival function is used in a broader range of applications, including human mortality. The survival function is the complementary cumulative distribution function of the lifetime ...
In the graph on left, a dose/survival curve for a hypothetical group of cells has been drawn with and without a rest time for the cells to recover. Other than the recovery time partway through the irradiation, the cells would have been treated identically. Radioresistance may be induced by exposure to small doses of ionizing radiation.
Typically the evaluation of relative biological effectiveness is done on various types of living cells grown in culture medium, including prokaryotic cells such as bacteria, simple eukaryotic cells such as single celled plants, and advanced eukaryotic cells derived from organisms such as rats. By irradiating batches of cells with different ...
A clonogenic assay is a cell biology technique for studying the effectiveness of specific agents on the survival and proliferation of cells. It is frequently used in cancer research laboratories to determine the effect of drugs or radiation on proliferating tumor cells [1] as well as for titration of Cell-killing Particles (CKPs) in virus stocks. [2]