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Equine estrogens, or horse estrogens ... Binding affinities were determined via displacement studies in a variety of in-vitro systems with labeled estradiol and ...
Oral CEEs 1.25 mg/daily and oral micronized estradiol 1 mg/daily result in similar plasma concentrations of estrone and estradiol (150–300 pg/mL and 30–50 pg/mL for micronized estradiol, respectively) (oral estradiol is extensively metabolized into estrone during hepatic first-pass metabolism), [67] although this does not account for ...
Tritiated estradiol radioactivity in blood with a single intramuscular injection of 1.5 to 2.8 μg tritiated estradiol in aqueous solution in four women. [1] Peak blood radioactivity occurred within 15 minutes in three of the women and in the remaining woman after 2 hours. [1] Source: Davis et al. (1963). [1]
Estradiol production during the menstrual cycle is 30–640 µg/d (6.4–8.6 mg total per month or cycle). The vaginal epithelium maturation dosage of estradiol benzoate or estradiol valerate has been reported as 5 to 7 mg/week. An effective ovulation-inhibiting dose of estradiol undecylate is 20–30 mg/month.
Synthetic estradiol, taken orally, decomposes when absorbed in the gastrointestinal tract and delivers bioidentical estradiol to the bloodstream. [23] The hormone estriol, produced during pregnancy, is frequently compounded into bioidentical preparations in the United States.
Estradiol levels with combined injectable contraceptives [16] Preparation Form Dose Estradiol C max Estradiol T max; EV/NETE: Oil solution 5 mg/50 mg 232–428 pg/mL 2 days EC/MPA: Aqueous suspension 5 mg/25 mg 184–736 pg/mL 2–4 days EEn/DHPA: Oil solution 10 mg/150 mg 314–317 pg/mL 4.2–8.1 days 5 mg/75 mg 148 pg/mL 6.5 days
Estradiol has been used at high doses to suppress sex drive in men with sexual deviance such as paraphilias and in sex offenders. [84] [85] [86] It has specifically been used for this indication in the forms of intramuscular injections of estradiol valerate and estradiol undecylate and of subcutaneous pellet implants of estradiol. [84] [85] [86]
The ratio of circulating estrone to circulating estradiol is the same at about 5:1 with both oral estradiol and oral estrone sulfate. [5] An investigational estrone vaginal ring was found to result in a ratio of estrone to estradiol of 4:1 or 5:1 initially, but this decreased to about 1:1 with continuous therapy.