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Contains 250 mg acetaminophen, 250 mg aspirin and 65 mg caffeine. 1969: Excedrin PM – Excedrin PM is the first headache and sleeping pill combination product. [8] Contains 500 mg acetaminophen and 38 mg diphenhydramine citrate as a sleep aid. Those same active ingredients were later utilized several years later in the product Tylenol PM.
Paracetamol, an analgesic and antipyretic substance, has slow onset but has a longer duration of action and is lacking anti-inflammatory properties. [3] On the other hand, propyphenazone, a non-steroidal anti-inflammatory drug (NSAID), is proven to have a faster onset but shorter duration of action. [4]
Caffeine has also been shown to reduce swelling around the eyes although this use is usually via a gel formula of caffeine. Caffeine exerts antioxidant effects, prevents UV skin damage, stimulates hair growth, and inhibits hair loss. These effects have made it an area of interest in adding caffeine to sunscreens, shampoos, and conditioners. [6]
Aspirin/paracetamol/caffeine is a combination drug for the treatment of pain, especially tension headache and migraine. [1] It contains aspirin , a non-steroidal anti-inflammatory drug ; paracetamol (acetaminophen), an analgesic ; and caffeine , a stimulant .
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Naproxen, sold under the brand name Aleve among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, menstrual cramps, and inflammatory diseases such as rheumatoid arthritis, gout and fever. [8] It is taken orally. [8] It is available in immediate and delayed release formulations. [8]
Non-steroidal anti-inflammatory drugs [1] [3] (NSAID) [1] are members of a therapeutic drug class which reduces pain, [4] decreases inflammation, decreases fever, [1] and prevents blood clots. Side effects depend on the specific drug, its dose and duration of use, but largely include an increased risk of gastrointestinal ulcers and bleeds ...
Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders.As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias.
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