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Guaifenesin might act as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi via stimulation of the gastric mucosa. . This stimulation leads to an increased parasympathetic activity in the respiratory tract via the so-called gastro-pulmonary reflex, although some in vitro studies suggested that it might also act directly on the ...
Ephedrine works by inducing the release of norepinephrine and hence indirectly activating the α-and β-adrenergic receptors. [11] Chemically, ephedrine is a substituted amphetamine and is the (1R,2S)-enantiomer of β-hydroxy-N-methylamphetamine. [14] Ephedrine was first isolated in 1885 and came into commercial use in 1926.
A number of studies have found acetaminophen (alone and in combination) to be effective [4] [5] and a safe treatment for common cold symptoms such as sore throat and body aches. In contrast, a systematic review including 26 randomized controlled trials compared the use of over-the-counter cough medicines with no treatment in children and adults ...
In 2004 Manoj Bhargava's company, Living Essentials LLC, launched a product called "5-Hour Energy". [5] [6] [7] By 2012, retail sales had grown to an estimated $1 billion. [5] A March 2011 article in Consumer Reports reported that, according to a lab test, a 2-US-fluid-ounce (59 ml) 5-Hour Energy contained 207 milligrams of caffeine, slightly ...
[3] [4] [5] However, at high dose, it may lead to cardiac arrhythmias, hypertension, seizures or other serious cardiovascular and/or central nervous system adverse effects. [6] [7] [8] Tedral is contraindicated in individuals with hypersensitivity to theophylline, ephedrine and/or phenobarbital.
Examples are ephedrine, phenylephrine, pseudoephedrine, and oxymetazoline. Fever or pain medication. Examples are paracetamol (acetaminophen) and NSAIDs such as ibuprofen or naproxen. Also employed are various substances supposed to soften the coughing, like honey or supplement syrup. An example combination is guaifenesin with codeine.
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