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Very-low-density lipoprotein (VLDL), density relative to extracellular water, is a type of lipoprotein made by the liver. [1] VLDL is one of the five major groups of lipoproteins (chylomicrons, VLDL, intermediate-density lipoprotein, low-density lipoprotein, high-density lipoprotein) that enable fats and cholesterol to move within the water-based solution of the bloodstream.
[2] [5] Remnant cholesterol is primarily chylomicron and VLDL, and each remnant particle contains about 40 times more cholesterol than LDL. [6] Remnant cholesterol corresponds to all cholesterol not found in high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C). It is calculated as total cholesterol minus HDL-C and LDL-C. [7]
Hyperlipidemia is abnormally high levels of any or all lipids (e.g. fats, triglycerides, cholesterol, phospholipids) or lipoproteins in the blood. [2] The term hyperlipidemia refers to the laboratory finding itself and is also used as an umbrella term covering any of various acquired or genetic disorders that result in that finding. [3]
Chylomicron structure ApoA, ApoB, ApoC, ApoE (apolipoproteins); T (triacylglycerol); C (cholesterol); green (phospholipids). Chylomicrons transport lipids absorbed from the intestine to adipose, cardiac, and skeletal muscle tissue, where their triglyceride components are hydrolyzed by the activity of the lipoprotein lipase, allowing the released free fatty acids to be absorbed by the tissues.
The N-terminus also consists of a glycine residue followed by 27 hydrophobic residues that constitute the signal peptide. [6] Following this region is an EGF repeat, a β-propeller segment that plays a role in the pH-dependent dissociation of the ligand-receptor complex, [8] and two more EGF repeats. [9]
A square root of a number x is a number r which, when squared, becomes x: =. Every positive real number has two square roots, one positive and one negative. For example, the two square roots of 25 are 5 and −5. The positive square root is also known as the principal square root, and is denoted with a radical sign:
A regular octahedron with an inscribed sphere, illustrating the square root of 6 ratio between edge length and radius Root rectangles illustrate a construction of the square root of 6 An equilateral triangle with circumscribed rectangle and square; the side of the square is (+) /, and the diagonal of the rectangle is the square root of 7. In ...
The square root of a positive integer is the product of the roots of its prime factors, because the square root of a product is the product of the square roots of the factors. Since p 2 k = p k , {\textstyle {\sqrt {p^{2k}}}=p^{k},} only roots of those primes having an odd power in the factorization are necessary.