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In August 2020, the U.S. Food and Drug Administration (FDA) became aware of nitrosamine impurities in certain samples of rifampin. [61] The FDA and manufacturers are investigating the origin of these impurities in rifampin, and the agency is developing testing methods for regulators and industry to detect the 1-methyl-4-nitrosopiperazine (MNP ...
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
Iron rings used in a laboratory. An iron ring or ring clamp is an item of laboratory equipment which comprises a conjoined metal ring and radially-extending rod. [1] In some cases, the rod terminates in a screw clamp for attachment to a retort stand or other support; in others, the rod may be attached to a stand by means of a laboratory clamp holder. [2]
Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
Marman clamps are used extensively in spaceflight systems and are common mechanical load-transfer and clamping mechanisms for connecting the upper stage and the satellite payload of space vehicles, [3] [4] for example, on the Cassini Plasma Spectrometer on the Cassini orbiter. They may also be used to join stages of a booster rocket. [3]
They are bicyclic ring systems containing a β-lactam moiety fused with a five-member thiazolidine ring. [1] Due to ring strain and limitations on amide resonance, the structure is unstable and highly susceptible to catalytic cleavage at the amide bond. [2] Benzylpenicillin (penicillin G) is the natural product parent that contains the penam ...
In November 2013, Ring was founded as Doorbot by Jamie Siminoff. Doorbot was crowdfunded via Christie Street, and raised US$ 364,000, more than the $250,000 requested. [1] [4] [5] Siminoff's team envisioned the product's concept as an "alarm system literally turned inside out" in comparison to other security systems, describing it as a "pre-crime" system. [6]
Rifapentine, sold under the brand name Priftin, is an antibiotic used in the treatment of tuberculosis. [2] In active tuberculosis it is used together with other antituberculosis medications. [2]