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MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. [5] MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2 , and functions as a pattern recognition receptor capable of detecting viruses .
RIG-I domain architecture. (A) Schematic representation of full-length RIG-I. (B) X-ray crystal structure of RNA-bound RIG-I ( ), excluding the CARD domains.The RLR receptors are members of the DEAD-box (SF2) helicase family (despite containing a DExD/H motif, rather than the DEAD motif characteristic of the family) and share a common domain architecture.
At a resting state for the cell, a protein called mitofusin 2 (MFN2) is known to interact with MAVS, preventing MAVS from binding to the cytosolic proteins, such as RIG-I and MDA5. [ 7 ] [ 8 ] Upon recognition of the virus in the cytosol, mitochondria-associated ER membranes (MAM) and mitochondria will become physically tethered by MFN2 and RIG ...
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Magyar Tudomány (Hungarian pronunciation: [ˈmɒɟɒr ˈtudomaːɲ], Hungarian: Hungarian Science) is the official monthly science magazine of the Hungarian Academy of Sciences. It publishes short articles on various new scientific developments as well as on problems of scientific life. Most articles are written by members of the academy.
Médiaszolgáltatás-támogató és Vagyonkezelő Alap (MTVA) (English: Media Services and Support Trust Fund) is a Hungarian fund company owned and financed by the Hungarian state, through the National Media and Infocommunications Authority (Hungarian: Nemzeti Média- és Hírközlési Hatóság, NMHH).
On July 1, 2015, Magyar Rádió and the three other public media organisations managed by the MTVA were merged into a single organisation called Duna Media Service (Hungarian: Duna Médiaszolgáltató). [3] This organization is the legal successor to Magyar Rádió and is an active member of the European Broadcasting Union. [4] [5]
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