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  2. Vitamin B12 - Wikipedia

    en.wikipedia.org/wiki/Vitamin_B12

    Injection of hydroxycobalamin is often used if digestive absorption is impaired, [2] but this course of action may not be necessary with high-dose oral supplements (such as 0.5–1.0 mg or more), [94] [95] because with large quantities of the vitamin taken orally, even the 1% to 5% of free crystalline B 12 that is absorbed along the entire ...

  3. Haptocorrin - Wikipedia

    en.wikipedia.org/wiki/Haptocorrin

    The same cells in the stomach that produce gastric hydrochloric acid, the parietal cells, also produce a molecule called the intrinsic factor (IF), which binds the B 12 after its release from haptocorrin by digestion, and without which only 1% of vitamin B 12 is absorbed. Intrinsic factor (IF) is a glycoprotein, with a molecular weight of 45 kDa.

  4. Intrinsic factor - Wikipedia

    en.wikipedia.org/wiki/Intrinsic_factor

    Because vitamin B 12 absorption is a multistep process that involves the stomach, pancreas and small intestine, and is mediated by two carriers: Haptocorrin and intrinsic factor, and because Haptocorrin (transcobalamin I) binds to vitamin B 12, and Vitamin B 12 is acid-sensitive, when vitamin B 12 binds to Haptocorrin it can safely pass through ...

  5. How vitamin B12 could give you an energy boost - AOL

    www.aol.com/finance/vitamin-b12-could-energy...

    That includes folks with an autoimmune disorder called pernicious anemia, who are unable to absorb B12, and people who take a lot of over-the-counter stomach-acid reducers, like famotidine ...

  6. Vitamin B12 Is a Power Nutrient. Here's How to Know If ... - AOL

    www.aol.com/vitamin-b12-power-nutrient-heres...

    The National Institutes of Health recommends that the average man consume a mere 2.4 micrograms a day, which is actually the lowest daily recommended dose of any vitamin. “Vitamin B12 ...

  7. Transcobalamin - Wikipedia

    en.wikipedia.org/wiki/Transcobalamin

    It primarily serves to protect cobalamin (Vitamin B12) from acid degradation in the stomach by producing a HC-Vitamin B 12 complex. Once the complex has traveled to the more pH-neutral duodenum, pancreatic proteases degrade haptocorrin, releasing free cobalamin, which now binds to intrinsic factor for absorption by ileal enterocytes.

  8. How vitamin B12 could give you an energy boost - AOL

    www.aol.com/finance/vitamin-b12-could-energy...

    Feeling low-energy? You could be among the estimated 3.6% of Americans who are deficient and 12.5% who get insufficient amounts of vitamin B12. Everyone requires a certain amount of B12 depending ...

  9. B vitamins - Wikipedia

    en.wikipedia.org/wiki/B_vitamins

    Because they are soluble in water, excess B vitamins are generally readily excreted, although individual absorption, use and metabolism may vary. [7] The elderly and athletes may need to supplement their intake of B 12 and other B vitamins due to problems in absorption and increased needs for energy production.

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