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Kidney stone disease, also known as renal calculus disease, nephrolithiasis or urolithiasis, is a crystallopathy where a solid piece of material (renal calculus) develops in the urinary tract. [2] Renal calculi typically form in the kidney and leave the body in the urine stream. [2] A small calculus may pass without causing symptoms. [2]
A number of important medical conditions are caused by stones: [citation needed] Nephrolithiasis (kidney stones) Can cause hydronephrosis (swollen kidneys) and kidney failure; Can predispose to pyelonephritis (kidney infections) Can progress to urolithiasis; Urolithiasis (urinary bladder stones) Can progress to bladder outlet obstruction
A kidney biopsy is the only way to diagnose thin basement membrane disease. It reveals thinning of the glomerular basement membrane from the normal 300 to 400 nanometers (nm) to 150 to 250 nm. However, a biopsy is rarely done in cases where the patient has isolated microscopic hematuria, normal kidney function, and no proteinuria.
The glomerular basement membrane is a tissue in the kidney that filters the blood. An abnormal glomerular basement membrane may allow red blood cells into the urinary space. Because kidney stones are so common in people with LPHS, crystals in the kidney tubules may also play a part in bleeding and pain. [4] Other speculations on cause include [5]
Visible hematuria must be investigated, as it may be due to a pathological cause. [1] [6] In those with visible hematuria, urological cancer (most frequently bladder or kidney cancer) is discovered in 20–25%. [3] Hematuria alone without accompanying symptoms should be raise suspicion of malignancy of the urinary tract until proven otherwise. [5]
In December 2003, a kidney stone weighing 356 g (12.5 oz) was removed from the right kidney of Peter Baulman of Australia. At its widest point, the stone measured 11.86 cm (4.66 in). [ 9 ] In 2017, a 2 kg (4.4 lb) stone spanning 20 cm was surgically removed from Abdul Abu Al Hajjar in Kensington , England.
CVA tenderness often indicates kidney pathology, but it may result from other medical problems. [4] CVA tenderness is often present in acute pyelonephritis . [ 5 ] [ 4 ] [ 6 ] [ 7 ] CVA tenderness may be present in patients who have a kidney stone , [ 8 ] [ 7 ] a stone in the ureter , [ 8 ] a ureteropelvic junction obstruction, [ 8 ] a kidney ...
The presence of hematuria, or blood in the urine, may indicate acute UTIs, kidney disease, kidney stones, inflammation of the prostate (in men), endometriosis (in women), or cancer of the urinary tract. In some cases, blood in the urine results from athletic training, particularly in runners. [citation needed]
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