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Heterologous desensitization may occur in cells that are grossly overstimulated for prolonged times by a certain agents. [4] Receptor desensitization, whether heterologous or homologous, may contribute to human pathology.
71223 Ensembl ENSG00000154165 ENSMUSG00000047293 UniProt P49685 Q0VDU3 RefSeq (mRNA) NM_005290 NM_001162955 RefSeq (protein) NP_005281 NP_001156427 Location (UCSC) Chr 3: 98.53 – 98.53 Mb Chr 16: 58.54 – 58.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse G protein-coupled receptor 15 is a protein that in humans is encoded by the GPR15 gene. GPR15 is a class A orphan G protein ...
In medicine, desensitization is a method to reduce or eliminate an organism's negative reaction to a substance or stimulus. In pharmacology , drug desensitization refers to two related concepts. First, desensitization may be equivalent to drug tolerance and refers to subjects' reactions (positive or negative) to a drug reducing following its ...
This results in ligand-induced desensitization or internalization of that receptor. This is typically seen in animal hormone receptors. This is typically seen in animal hormone receptors. Upregulation of receptors, on the other hand, can result in super-sensitized cells, especially after repeated exposure to an antagonistic drug or prolonged ...
Homologous desensitization is distinguished from heterologous desensitization, a process in which repeated stimulation of a receptor by an agonist results in desensitization of the stimulated receptor as well as other, usually inactive, receptors on the same cell. They are sometimes denoted as agonist-dependent and agonist-independent ...
G-protein-coupled receptor kinase 3 (GRK3) is an enzyme that in humans is encoded by the ADRBK2 gene. [5] GRK3 was initially called Beta-adrenergic receptor kinase 2 (βARK-2), and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar to GRK2.
Prostaglandin E 2 receptor 4 (EP 4) is a prostaglandin receptor for prostaglandin E2 (PGE 2) encoded by the PTGER4 gene in humans. [5] It is one of four identified EP receptors, the others being EP 1, EP 2, and EP 3, all of which bind with and mediate cellular responses to PGE 2 and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin ...
Prostaglandin E 2 receptor 1 (EP 1) is a 42kDa prostaglandin receptor encoded by the PTGER1 gene. EP 1 is one of four identified EP receptors, EP 1, EP 2, EP 3, and EP 4 which bind with and mediate cellular responses principally to prostaglandin E 2) (PGE 2) and also but generally with lesser affinity and responsiveness to certain other prostanoids (see Prostaglandin receptors). [5]