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Hyperacute rejection manifests severely and within minutes, and so treatment is immediate: removal of the tissue. Acute rejection is treated with one or several of a few strategies. Despite treatment, rejection remains a major cause of transplant failure. [ 36 ]
Furthermore, hyperacute rejection necessitates immediate medical intervention, often leading to the removal of the rejected kidney and the need to explore alternative treatment options, such as returning to dialysis or seeking another transplant source.
[2] [19] Adults are significantly likely to suffer from hyperacute rejection, [1] thrombosis, or death, but could be considered to be an acceptable risk if the alternative is death. [6] In the case of ABOi renal transplantation, aggressive antibody removal is required, along with supplemental medication, with the resulting condition being ...
Hyperacute and accelerated rejection is antibody-mediated immune response to the allograft. Recipient's blood already contains circulating antibodies before the transplantation [3] – either IgM or antibodies incurred by previous immunization (e.g. by repeated blood transfusion).
Common causes of acute rejection include inadequate immunosuppression treatment or non-compliance with the immunosuppressive regiment. [79] Clinical acute rejection (seen in approximately 10-15% of kidney transplants within the first year of transplantation) presents as kidney rejection with associated kidney dysfunction. [79]
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[10] [28] Acute rejection arises within the first week to 6 months after transplantation and could be further categorised into acute humoral rejection or acute cellular rejection. [10] [28] Chronic rejection is the loss of graft function due to sustained immune response against the graft, leading to the functional loss of tissue graft from ...
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