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1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC, EDAC or EDCI) is a water-soluble carbodiimide usually handled as the hydrochloride. [1] It is typically employed in the 4.0-6.0 pH range. It is generally used as a carboxyl activating agent for the coupling of primary amines to yield amide bonds.
A common way to synthesize an NHS-activated acid is to mix NHS with the desired carboxylic acid and a small amount of an organic base in an anhydrous solvent. A coupling reagent such as dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) is then added to form a highly reactive activated acid intermediate.
Ethacizine (ethacyzine) is a class Ic antiarrhythmic agent, related to moracizine. [2] It is used in Russia and some other CIS countries for the treatment of severe and/or refractory ventricular and supraventricular arrhythmias, especially those accompanied by organic heart disease.
Meptazinol, sold under the brand name Meptid, is an opioid analgesic developed by Wyeth in the 1970s. [1] Indications for use in moderate to severe pain, most commonly used to treat pain in obstetrics . Meptazinol is a 3-phenylazepane derivative, whereas the other phenazepanes like ethoheptazine and proheptazine are 4-phenylazepanes.
Ethyl cyanohydroxyiminoacetate (oxyma) is the oxime of ethyl cyanoacetate and finds use as an additive for carbodiimides, such as dicyclohexylcarbodiimide (DCC) in peptide synthesis. It acts as a neutralizing reagent for the basicity or nucleophilicity of the DCC due to its pronounced acidity ( pKa 4.60) and suppresses base catalyzed side ...
Some estimates of lethality with BZ have been grossly erroneous, and ultimately the safety margin for BZ is inconclusive due to lack of human data at higher dosage ranges, though some researchers have estimated it to be 0.5 to 3.0 mg/kg and an LD 01 is 0.2 to 1.4 mg/kg (Rosenblatt, Dacre, Shiotsuka, & Rowlett, 1977). [7]
Tapentadol is used medically for the treatment of moderate to severe pain. [2] It is addictive, a commonly abused drug, [2] [9] [10] and poses a high risk of physical and/or mental dependence. [11] [12] Analgesia occurs within 32 minutes of oral administration, and lasts for 4–6 hours. [13]
It is available as tablets containing 2 or 4 mg. It was patented in 1984 and approved for medical use in 1991. [1] References External links. Motens 2 mg Summary of ...