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para-Methoxyphenylpiperazine (pMeOPP), also known as 4-methoxyphenylpiperazine (4-MeOPP), is a substituted piperazine derivative with stimulant effects which has been sold as an ingredient in "Party pills", initially in New Zealand and subsequently in other countries around the world. [1]
[1] [2] [4] This is in contrast to the related drug meta-chlorophenylpiperazine (mCPP), which shows high affinity for both the serotonin 5-HT 1A and 5-HT 2 receptors. [ 5 ] [ 2 ] oMeOPP and mCPP have both been found to suppress conditioned avoidance responses (CARs) without markedly affecting escape behavior in animals, indicative that they ...
Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C 4 H 10 N 2 ·2C 6 H 8 O 7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C 4 H 10 N 2 ·C 6 H 10 O 4 (containing 1 molecule each of piperazine and adipic acid).
1-Phenylpiperazine (1-PP or PP) is a simple chemical compound and drug featuring a phenyl group bound to a piperazine ring. [1] The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class. [2] It is a rigid analogue of amphetamine.
Substituted piperazines are a class of chemical compounds based on a piperazine core. [1] Some are used as recreational drugs and some are used in scientific research . [ 2 ]
1-(3,4-Methylenedioxybenzyl)piperazine (MDBZP, piperonylpiperazine) is a chemical compound of the piperazine chemical class related to benzylpiperazine (BZP). MDBZP has been sold as a designer drug [ 1 ] and has even been found as an ingredient in street Ecstasy pills.
The odors tend to be undesirable, as in the case of certain wines, [1] or as defensive chemicals used by insects such as Harmonia axyridis which produces isopropyl methoxy pyrazine (IPMP). They have also been identified as additives in cigarette manufacture. Detection thresholds are very low, typically near 2 parts per trillion (1 ng/L). [1]
Unlike the related piperazine compound meta-chlorophenylpiperazine (mCPP), TFMPP has insignificant affinity for the 5-HT 3 receptor (IC 50 = 2,373 nM). [7] TFMPP also binds to the SERT (EC 50 = 121 nM) and evokes the release of serotonin. [6] It has no effects on dopamine or norepinephrine reuptake or efflux. [6]