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  2. Asparaginase - Wikipedia

    en.wikipedia.org/wiki/Asparaginase

    Asparaginase is an enzyme that is used as a medication and in food manufacturing. [6] [7] As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). [6] It is given by injection into a vein, or muscle. [6] A pegylated version is also available. [8] In food manufacturing it is used to ...

  3. Asparagine synthetase - Wikipedia

    en.wikipedia.org/wiki/Asparagine_synthetase

    However, the opposite effect is visible in cases of asparaginase resistant cancers. [3] In these resistant cancers, the effect of blood asparagine depletion through L-asparaginase instead leads to significant asparagine synthetase overexpression to compensate, effectively nullifying the effect of the chemotherapy drug. [3]

  4. Plant sources of anti-cancer agents - Wikipedia

    en.wikipedia.org/wiki/Plant_sources_of_anti...

    There can be many years between promising laboratory work and the availability of an effective anti-cancer drug: Monroe Eliot Wall discovered anti-cancer properties in Camptotheca in 1958, but it was not until 1996 – after further research and rounds of clinical trials – that topotecan, a synthetic derivative of a chemical in the plant, was ...

  5. ASRGL1 - Wikipedia

    en.wikipedia.org/wiki/ASRGL1

    66514 Ensembl ENSG00000162174 ENSMUSG00000024654 UniProt Q7L266 Q8C0M9 RefSeq (mRNA) NM_001083926 NM_025080 NM_025610 RefSeq (protein) NP_001077395 NP_079356 NP_079886 Location (UCSC) Chr 11: 62.34 – 62.39 Mb Chr 19: 9.09 – 9.11 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse L-asparaginase is an enzyme that in humans is encoded by the ASRGL1 gene. Function The ASRGL1 protein ...

  6. Targeted alpha-particle therapy - Wikipedia

    en.wikipedia.org/wiki/Targeted_alpha-particle...

    Some α emitting isotopes such as 225 Ac and 213 Bi are only available in limited quantities from 229 Th decay, although cyclotron production is feasible. [9] [10] [11] Among alpha-emitting radiometals according to availability, chelation chemistry, and half-life, 212 Pb is also a promising candidate for targeted alpha-therapy.

  7. Alkylating antineoplastic agent - Wikipedia

    en.wikipedia.org/wiki/Alkylating_antineoplastic...

    An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (C n H 2n+1) to DNA. [1] Since cancer cells, in general, proliferate faster and with less error-correcting than healthy cells, cancer cells are more sensitive to DNA damage—such as being alkylated. Alkylating agents are used to ...

  8. Selinexor - Wikipedia

    en.wikipedia.org/wiki/Selinexor

    Selinexor sold under the brand name Xpovio among others, is a selective inhibitor of nuclear export used as an anti-cancer medication.It works by blocking the action of exportin 1 [6] and thus blocking the transport of several proteins involved in cancer-cell growth from the cell nucleus to the cytoplasm, which ultimately arrests the cell cycle and leads to apoptosis. [8]

  9. Nitrogen mustard - Wikipedia

    en.wikipedia.org/wiki/Nitrogen_mustard

    Other compounds used in cancer chemotherapy that have the ability to form ICLs are cisplatin, mitomycin C, carmustine, and psoralen. [18] These kinds of lesions are effective at forcing the cell to undergo apoptosis via p53 , [ citation needed ] a protein which scans the genome for defects.