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Some drugs need to be used with caution in patients with renal dysfunction. The use of nitrofurantoin is contraindicated in patients with an estimated GFR of less than 30 mL/min/1.73m 2 as drug accumulation can lead to increased side effects and impaired recovery of the urinary tract, increasing the risk of treatment failure. [29]
Antibiotics are known to disrupt the gut, urinary tract, and vaginal microbiota. [14] This has been associated with increased risk of recurrent UTIs. [14] Methenamine has been limitedly studied in this regard, but was found in one small study to preserve urinary microbial diversity. [14]
Antibacterials like dapsone (increases plasma levels of both drugs), methenamine (increased risk of crystalluria) and rifampicin (as it may lead to an increased plasma level of rifampicin and lower plasma levels of trimethoprim) Anticoagulants like warfarin and acenocoumarol — anticoagulant effects of either drug is potentiated by this ...
Cefiderocol, sold under the brand name Fetcroja (by Shionogi) among others, is an antibiotic used to treat complicated urinary tract infections when no other options are available. [5] It is indicated for the treatment of multi-drug-resistant Gram-negative bacteria including Pseudomonas aeruginosa. [6] [7] [8] It is given by injection into a ...
Fosfomycin, sold under the brand name Monurol among others, is an antibiotic primarily used to treat lower urinary tract infections. [8] It is not indicated for kidney infections. [8] Occasionally it is used for prostate infections. [8] It is generally taken by mouth. [8]
Sulfadiazine is available in multiple generic tablets of 500 mg. For urinary tract infections, the usual dose is 4 to 6 grams daily in 3 to 6 divided doses. [4] Common side effects include nausea, diarrhea, headache, fever, rash, depression, and pancreatitis. [1]
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea. [1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS. [1] [2] It is taken orally (swallowed by mouth). [1]
Cefuroxime, sold under the brand name Zinacef among others, is a second-generation cephalosporin [3] antibiotic used to treat and prevent a number of bacterial infections. [4] These include pneumonia, meningitis, otitis media, sepsis, urinary tract infections, and Lyme disease. [5] It is used by mouth or by injection into a vein or muscle. [5]
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