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The iPLEDGE Program was instituted as a replacement for the failed SMART program (System to Manage Accutane Related Teratogenicity). [14] Instituted in April 2002, SMART aimed to eliminate isotretinoin-induced birth defects by preventing exposure to the drug during pregnancy.
Pre-iPledge, there was the Accutane Pregnancy Prevention Program, which was developed in the late 1980s. It asked much of the same things iPledge does: monthly pregnancy tests, use of ...
Many dermatologists and patients say they haven't been able to get isotretinoin (formerly Accutane) since a mid-December update to the iPledge website. Patients going weeks, months without acne ...
Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication used to treat skin diseases like harlequin-type ichthyosis, and lamellar ichthyosis, and severe cystic acne or moderate acne that is unresponsive to antibiotics. [6]
[103] iPledge requires the woman to have two negative pregnancy tests and to use two types of birth control for at least one month before isotretinoin therapy begins and one month afterward. [103] The effectiveness of the iPledge program is controversial due to continued instances of contraception nonadherence. [103] [104]
Accutane causes the skin on the lips to shed so quickly that it can cause thick, chunky flakes to come off, which can worsen and become red if you pick the skin off, says Goldman. He recommends ...
The REMS program developed out of previous systems dating back to the 1980s for monitoring the use of a small number of high-risk drugs such as the Accutane, which causes serious birth defects, Clozaril, which can cause agranulocytosis, and Thalidomide, which is used to treat leprosy but causes serious birth defects. [4]
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