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The AUC (area under the curve) of the ROC curve reflects the overall accuracy and the separation performance of the biomarker (or biomarkers), [3] and can be readily used to compare different biomarker combinations or models. [4] As a rule of thumb, the fewer the biomarkers that one uses to maximize the AUC of the ROC curve, the better.
ANAM has a long and continuous history of research in the Department of Defense, including sports concussion studies at West Point and Traumatic Brain Injury (TBI) studies during Ft. Bragg Paratrooper training. Through these and other programs, nearly two million ANAM test sessions have been collected.
An example is the traumatic brain injury (TBI) blood-based biomarker test consisted of measuring the levels of neuronal Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and Glial fibrillary acidic protein (GFAP) to aid in the diagnosis of the presence of cranial lesion(s) among moderate to mild TBI patients that is(are) otherwise only ...
In medicine, a biomarker is a measurable indicator of the severity or presence of some disease state. It may be defined as a "cellular, biochemical or molecular alteration in cells, tissues or fluids that can be measured and evaluated to indicate normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention."
Cat genetics describes the study of inheritance as it occurs in domestic cats. In feline husbandry it can predict established traits ( phenotypes ) of the offspring of particular crosses. In medical genetics , cat models are occasionally used to discover the function of homologous human disease genes.
Genetic Testing and Molecular Biomarkers is a monthly peer reviewed scientific journal published by Mary Ann Liebert, Inc. The editor-in-chief is Garth Ehrlichs . The journal covers genetic testing research along with associated ethical, legal, social, and economic issues.
The CTX test measures for the presence and concentration of a crosslink peptide sequence of type I collagen, found, among other tissues, in bone. This specific peptide sequence relates to bone turnover because it is the portion that is cleaved by osteoclasts during bone resorption, and its serum levels are therefore proportional to osteoclastic ...
A DNA test which identifies markers associated with cerebellar abiotrophy became available in 2008. [8] The test was refined to identify the most likely mutations, and retesting of earlier samples based on an earlier indirect marker test developed by UCD, [ 9 ] indicated a 97% accuracy rate for the old test relative to the newer version, with ...