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In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
An oral dose of 3 mg per kilogram of body weight causes the death of 50% of the rats exposed (LD 50), showing a very high selectivity when compared for example to monkeys ( 4000 mg per kilogram of body weight). [13] However other studies have shown a much higher efficacy for dogs (a LD 50 of 0.38 mg/kg). [14]
The median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 (lethal concentration and time) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after a specified test duration.
LT50 is the median Lethal Time (time until death) [1] [2] after exposure of an organism to a toxic substance or stressful condition. LT50 is commonly used in toxicology studies to quantify amount of a stressor necessary to kill an organism. LT50 can be used in conjunction with EC50 (median Exposure Concentration) for even more precise ...
The LD50, or 50% lethal dose of DCPA, is greater than 10,000 mg/kg in beagle dogs. In humans, it seems that DCPA is poorly absorbed, as 6% of a 25-mg dose and 12% of a 50-mg dose were absorbed according to metabolites in urine.
Median lethal (LD 50) doses of theobromine have only been published for cats, dogs, rats, and mice; these differ by a factor of 6 across species.[6]Serious poisoning happens more frequently in domestic animals, which metabolize theobromine much more slowly than humans, [7] and can easily consume enough chocolate to cause poisoning.
Absolute lethal concentration, LC 100; Absolute lethal dose, LD 100 The most referenced value in the chemical industry is the median lethal dose, or LD50. This is the concentration of substance which resulted in the death of 50% of test subjects (typically mice or rats) in the laboratory.
The LD 50 in mice is 0.045 μg/kg and in rats 0.089 μg/kg. In other mammals (rabbits, dogs, monkeys and guinea pigs) the LD 50 is ranged between 0.025 and 0.45 μg/kg. They all died in several minutes from heart failure. [2] The lethal dose for mice by the intratracheal route is above 2 μg/kg in 2 hours.
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