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Tirbanibulin, sold under the brand name Klisyri, is a medication used for the treatment of actinic keratosis (AK) on the face or scalp. [4][5][6] It functions by inhibiting both tubulin polymerization and Src kinase signaling. [7] It is potentially effective in impeding the development of squamous cell carcinoma in situ.
Fluorouracil. Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. [3] By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer. [3]
Topical 5-FU is the most utilized treatment for AK, and often results in effective removal of the lesion. [51] Overall, there is a 50% efficacy rate resulting in 100% clearance of AKs treated with topical 5-FU. [52] [53] 5-FU may be up to 90% effective in treating non-hyperkeratotic lesions. [54]
Specialty. Dermatology. Actinic cheilitis is cheilitis (lip inflammation) caused by long term sunlight exposure. Essentially it is a burn, [2] and a variant of actinic keratosis which occurs on the lip. [5] It is a premalignant condition, [6] as it can develop into squamous cell carcinoma (a type of mouth cancer).
A gel formulation of the drug has been approved by the U.S. Food and Drug Administration (FDA) [3] and by the European Medicines Agency (EMA) [4] for the topical treatment of actinic keratosis. Two different strengths of the gel have been approved for use on either the face and scalp (0.015%) or the trunk and extremities (0.05%), respectively. [5]
Hard lump with a scaly top or ulceration. [1] Cutaneous squamous-cell carcinoma (cSCC), also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer, is one of the three principal types of skin cancer, alongside basal-cell carcinoma and melanoma. [10] cSCC typically presents as a hard lump with a scaly surface, though it may ...
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