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CRAM was designed to be an efficient reference-based alternative to the Sequence Alignment Map (SAM) and Binary Alignment Map (BAM) file formats. It optionally uses a genomic reference to describe differences between the aligned sequence fragments and the reference sequence, reducing storage costs.
SAMtools makes it possible to work directly with a compressed BAM file, without having to uncompress the whole file. Additionally, since the format for a SAM/BAM file is somewhat complex - containing reads, references, alignments, quality information, and user-specified annotations - SAMtools reduces the effort needed to use SAM/BAM files by ...
The compressed ROM/RAM file system (or cramfs) is a free (GPL'ed) read-only Linux file system designed for simplicity and space-efficiency. It is mainly used in embedded and small-footprint systems. Unlike a compressed image of a conventional file system, a cramfs image can be used as it is, i.e. without first decompressing it.
Created Date: 8/30/2012 4:52:52 PM
Binary Alignment Map (BAM) is the comprehensive raw data of genome sequencing; [1] it consists of the lossless, compressed binary representation of the Sequence Alignment Map-files.
While standard data compression tools (e.g., zip and rar) are being used to compress sequence data (e.g., GenBank flat file database), this approach has been criticized to be extravagant because genomic sequences often contain repetitive content (e.g., microsatellite sequences) or many sequences exhibit high levels of similarity (e.g., multiple genome sequences from the same species).
Biological sequence formats are a collection of file formats that are used in the biomedical sciences. There are a number of these. There are a number of these. Most of these formats were developed for use in particular programmes and have subsequently been reused by other programmes.
Jealousy was a big part of why it hurts so much. And my way of getting out of problems is to study. So, I thought I have to learn my way out of this.” ...