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Pertuzumab is administered as an intravenous infusion in combination with trastuzumab and docetaxel as a first line treatment for HER2-positive metastatic breast cancer. [4] [3] It is also used in the same combination as a neoadjuvant (given to reduce the size of a tumor, prior to surgery or radiation) for HER2-positive early breast cancer; as of 2016 this use had not been shown to increase ...
In finance, a coupon is the interest payment received by a bondholder from the date of issuance until the date of maturity of a bond. [ 1 ] Coupons are normally described in terms of the "coupon rate", which is calculated by adding the sum of coupons paid per year and dividing it by the bond's face value . [ 2 ]
For certain specialty drugs (most injectables and biologic agents), drug coupons have been found to save patients as much as $6 of every $10 they are asked to pay out-of-pocket. [114] According to a 2017 study, for statin drugs, coupon users had higher drug utilization rates and lower rates of discontinuation than for non coupon users. [115]
coupons redeemed Future value, coupons reinvested Starting balance Interest, 5% Cash in/out Ending balance Starting balance Interest, 5% Cash in/out Ending balance Investment -1000 -1000 1st year coupon 1000 50 50 1000 1000 50 0 1050 2nd year coupon 1000 50 50 1000 1050 52.5 0 1102.5 3rd year coupon + bond 1000 50 1050 0 1102.5 55.125 1157.625 0
Sunday off-premises sales allowed as of May 20, 2012; [28] [29] Sunday on-premises sales subject to local ordinances. Beer can be purchased at grocery/convenience stores. Spirits and wine can be purchased only at liquor stores. No off-premises alcohol sales on Thanksgiving, Christmas Day, and New Year's Day.
E-ZPass is an electronic toll collection system used on toll roads, toll bridges, and toll tunnels in the Eastern, Midwestern, and Southeastern United States.The E-ZPass Interagency Group (IAG) consists of member agencies in several states, which use the same technology and allow travelers to use the same transponder on toll roads throughout the network.
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