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Social neuroscience is an interdisciplinary field devoted to understanding the relationship between social experiences and biological systems.Humans are fundamentally a social species, and studies indicate that various social influences, including life events, poverty, unemployment and loneliness can influence health related biomarkers.
The neural plate folds in upon itself to form the neural tube, which will later differentiate into the spinal cord and the brain, eventually forming the central nervous system. [2] Computer simulations found that cell wedging and differential proliferation are sufficient for mammalian neurulation. [3]
The remainder of the ectoderm gives rise to the epidermis. The ability of the mesoderm to convert the overlying ectoderm into neural tissue is called neural induction. In the early embryo, the neural plate folds outwards to form the neural groove. Beginning in the future neck region, the neural folds of this groove close to create the neural tube.
RGCs are the primary stem cells of the mammalian CNS, and reside in the embryonic ventricular zone, which lies adjacent to the central fluid-filled cavity (ventricular system) of the neural tube. [5] [6] Following RGC proliferation, neurogenesis involves a final cell division of the parent RGC, which produces one of two possible outcomes. First ...
In embryonic life, the SVZ refers to a secondary proliferative zone containing neural progenitor cells, which divide to produce neurons in the process of neurogenesis. [3] The primary neural stem cells of the brain and spinal cord, termed radial glial cells , instead reside in the ventricular zone (VZ) (so-called because the VZ lines the inside ...
A neurosphere is a culture system composed of free-floating clusters of neural stem cells. Neurospheres provide a method to investigate neural precursor cells in vitro. Putative neural stem cells are suspended in a medium lacking adherent substrates but containing necessary growth factors, such as epidermal growth factor and fibroblast growth ...
Methyl-CpG binding protein 1 represses miR-184, which is a microRNA responsible for proliferation of adult neural stem/progenitor cells (aNSCs) along with the inhibition of differentiating these cells. miR-184 regulates embryonic brain development by binding to the mRNA for the Numblike (Numbl) protein and altering its expression.
One example is the difference in function between presynaptic neurexin-1 containing an insert in SS4 (Nrxn1−SS4+) and neurexin-1 lacking an insert in SS4 (Nrxn1−SS4+) generated by alternative splicing. Nrxn1−SS4+ is involved in the trans-synaptic increase in postsynaptic NMDAR levels. [31] [29] Other SAMs have a similar diversity in function.