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The digestive system has a complex system of motility and secretion regulation which is vital for proper function. This task is accomplished via a system of long reflexes from the central nervous system (CNS), short reflexes from the enteric nervous system (ENS) and reflexes from GI peptides working in harmony with each other. [4]
The pancreas is a major organ functioning as an accessory digestive gland in the digestive system. It is both an endocrine gland and an exocrine gland . [ 28 ] The endocrine part secretes insulin when the blood sugar becomes high; insulin moves glucose from the blood into the muscles and other tissues for use as energy.
Layers of the Alimentary Canal.The wall of the alimentary canal has four basic tissue layers: the mucosa, submucosa, muscularis, and serosa. The enteric nervous system in humans consists of some 500 million neurons [11] (including the various types of Dogiel cells), [1] [12] 0.5% of the number of neurons in the brain, five times as many as the one hundred million neurons in the human spinal ...
The acid and semi-digested fats in the duodenum trigger the enterogastric reflex – the duodenum sends inhibitory signals to the stomach by way of the enteric nervous system, and sends signals to the medulla that (1) inhibit the vagal nuclei, thus reducing vagal stimulation of the stomach, and (2) stimulate sympathetic neurons, which send ...
In most vertebrates, digestion is a multistage process in the digestive system, starting from ingestion of raw materials, most often other organisms. Ingestion usually involves some type of mechanical and chemical processing. Digestion is separated into four steps: Ingestion: placing food into the mouth (entry of food in the digestive system),
Later studies showed that most of the gut peptides, such as secretin, cholecystokinin or substance P, were found to play a role of neurotransmitters and neuromodulators in the central and peripheral nervous systems. [1] Enteroendocrine cells do not form glands but are spread throughout the digestive tract.
The enteric nervous system directly controls the gut motility, whereas the extrinsic nerve pathways influence gut contractility indirectly through modifying this enteric innervation. [3] In almost all cases of neurogenic bowel dysfunction it is the extrinsic nervous supply affected and the enteric nervous supply remains intact.
The enteric nervous system also makes use of more than 30 neurotransmitters, most of which are identical to the ones found in CNS, such as acetylcholine, dopamine, and serotonin. More than 90% of the body's serotonin lies in the gut, as well as about 50% of the body's dopamine; the dual function of these neurotransmitters is an active part of ...
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