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The exposome is a concept used to describe environmental exposures that an individual encounters throughout life, and how these exposures impact biology and health. It encompasses both external and internal factors, including chemical, physical, biological, and social factors that may influence human health.
Exposome (2005) Exposomics: An individual's environmental exposures, including in the prenatal environment: Molecular genetics: A proposed term and field of study of the disease-causing effects of environmental factors (the "nurture" component of "nature vs. nurture"). [5] Exposome (2009) Composite occupational exposures and occupational health ...
The exposome encompasses the set of human environmental (i.e. non-genetic) exposures from conception onwards, complementing the genome. The exposome was first proposed in 2005 by cancer epidemiologist Christopher Paul Wild in an article entitled "Complementing the genome with an "exposome": the outstanding challenge of environmental exposure ...
Exosomes were first discovered in the maturing mammalian reticulocyte (immature red blood cell) by Stahl and group in 1983 [16] and Johnstone and group in 1983 [17] further termed 'exosomes' by Johnstone and group in 1987. [18]
Adducts may arise as a consequence of the chemical reaction between a given "physicochemical agent to which an organism is exposed across the lifespan" (sometimes referred to as the exposome). These physicochemical agents can be exogenous in origin, and include ionizing and non-ionizing radiation, the diet, lifestyle factors, pollution, and ...
Exposome-NL is a 10-year Dutch research program of multiple Dutch universities collaborating in the field of exposome research. Researchers from fields such as exposure science, environmental science, cardiovascular and metabolic health, clinical epidemiology, nutritional epidemiology, geosciences, agent-based modelling, molecular biology, chemistry and bioinformatics, and biostatistics ...
The Toxin and Toxin-Target Database (T3DB), [1] [2] also known as the Toxic Exposome Database, is a freely accessible online database of common substances that are toxic to humans, along with their protein, DNA or organ targets. The database currently houses nearly 3,700 toxic compounds or poisons described by nearly 42,000 synonyms.
Vineis main work is on the impact of environmental changes (including air pollution and climate change) on human health and molecules. This includes the use of omics technologies in epidemiological studies, that is the quantitative measurement of global sets of molecules in biological samples using high-throughput techniques, in combination with advanced biostatistics and bioinformatics tools.