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Conditioning treatment before haematopoietic stem cell transplantation (high dose, IV), chronic myeloid leukaemia, myelofibrosis, polycythaemia vera and essential thrombocytosis Myelosuppression, seizures (high dose), tachycardia (high dose), hepatic sinusoidal obstruction syndrome (high dose), Addison-like syndrome (rare), pulmonary fibrosis ...
In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the allergen cross-links Immunoglobulin E , tyrosine kinases rapidly signal into the cell, leading to cell degranulation and the release of histamine (and other chemical mediators ...
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. [9] Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal.
Treatment to protect the airway may include intubation or cricothyroidotomy. [1] Histamine-related angioedema can be treated with antihistamines , corticosteroids , and epinephrine . [ 1 ] In those with bradykinin-related disease a C1 esterase inhibitor , ecallantide , or icatibant may be used. [ 1 ]
Antiserum or drug treatment should be stopped as soon as possible. [2] [3] Once treatment has stopped, symptoms usually resolve within seven days. [3] Outcomes are generally good. [4] Corticosteroids, antihistamines, and analgesics are the main line of treatment. [3] The choice depends on the severity of the reaction. Prednisone may be used in ...
The incidence of life-threatening hypersensitivity reactions occurring during surgery and anesthesia is around one in 10,000 procedures. [1] Severe allergic reactions to anesthetic medications are rare and are usually attributable to factors other than the anesthetic.
Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication. [8] It is used in the treatment of itchiness, anxiety, insomnia, and nausea (including that due to motion sickness). [8] It is used either by mouth or injection into a muscle. [8] Hydroxyzine works by blocking the effects of histamine. [9]
The efferent neural pathway then follows, with relevant signals transmitted back from the cerebral cortex and medulla via the vagus and superior laryngeal nerves to the glottis, external intercostals, diaphragm, and other major inspiratory and expiratory muscles. The mechanism of a cough is as follows: