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Use in pregnancy and breastfeeding is not recommended. [3] Losartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by decreasing the ability of the kidneys to absorb electrolytes. [1] The combination was approved for medical use in the United States in 1995. [1] It is available as a generic medication. [2]
Up to six weeks may be required for the full effects to occur. [4] Common adverse effects include muscle cramps, stuffy nose, dizziness, cough, high blood potassium, and anemia. [4] Severe adverse effects may include angioedema, low blood pressure, and kidney problems. [4] Use during pregnancy may result in harm to the baby.
The use of valsartan in pregnancy is avoided due to the potential risk of fetal toxicity. [11] The U.S. Food and Drug Administration has a black box warning for valsartan/hydrochlorothiazide use during pregnancy. [2] The use of hydrochlorothiazide is avoided in those with anuria or severe kidney disease. [12]
A woman who miscarried was fined by the NHS for claiming a free prescription while pregnant.. Sadie Hawkes, 33, lost her baby before she had received the maternity exemption certificate that ...
However, not all of them are safe to use during pregnancy. One of the components of bismuth subsalicylate is salicylate, which is a component that crosses the placenta. Due to this, there is an increased risk for intrauterine growth retardation, fetal hemorrhage, and maternal hemorrhage within organogenesis and in the second/third trimester. [12]
Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine. [4]
Medical reasons for inducing or performing an abortion are usually due to concerns about fetal viability or disability. These reasons include chromosomal and genetic abnormalities, [6] structural abnormalities, [7] and fetal reduction. [8] The medical reasons may also be about the ability of the mother to survive the pregnancy without injury.
Use in pregnancy and breastfeeding is not recommended. [4] It is among a class of drugs called ACE inhibitors and works by decreasing renin-angiotensin-aldosterone system activity. [3] Quinapril was patented in 1980 and came into medical use in 1989. [5] It is available as a generic medication. [6]