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[113] [114] Long-term use of benzodiazepines in the elderly can lead to a pharmacological syndrome with symptoms including drowsiness, ataxia, fatigue, confusion, weakness, dizziness, vertigo, syncope, reversible dementia, depression, impairment of intellect, psychomotor and sexual dysfunction, agitation, auditory and visual hallucinations ...
Myasthenia gravis – This condition is characterized by muscle weakness, so a muscle relaxant such as lorazepam may exacerbate symptoms. Pregnancy and breastfeeding – Lorazepam belongs to the Food and Drug Administration (FDA) pregnancy category D, which means it is likely to cause harm to the developing baby if taken during the first ...
Symptoms may include tinnitus, [29] [125] psychosis, cognitive deficits, gastrointestinal complaints, insomnia, paraesthesia (tingling and numbness), pain (usually in limbs and extremities), muscle pain, weakness, tension, painful tremor, shaking attacks, jerks, dizziness and blepharospasm [20] and may occur even without a pre-existing history ...
More serious weakness of core and limb muscles may present. [7] A dietary deficiency of vitamin D is most commonly associated with osteoporosis, but can cause ANIM as well. Vitamin D induced ANIM is most commonly associated with sleep deprivation as it induces tonsillar and adenotonsillar hypertrophy, as well as weakens the airway muscles. [8]
Midazolam is the most commonly prescribed for this use because of its strong sedative actions and fast recovery time, as well as its water solubility, which reduces pain upon injection. Diazepam and lorazepam are sometimes used. Lorazepam has particularly marked amnesic properties that may make it more effective when amnesia is the desired effect.
The mechanism underlying rapid response to benzodiazepines and zolpidem in catatonia is unknown. [6] The observation that zolpidem, a selective hypnosedative with little to no muscle relaxing properties, elicits a challenge response similar to benzodiazepines has called into question the hypothesis that lorazepam may reverse catatonia through myorelaxation.
The failure of the electrical insulation surrounding nerves, the myelin, is seen in certain deficiency diseases, such as the failure of the body's system for absorbing vitamin B-12. [ 3 ] Diseases of the motor end plate include myasthenia gravis , a form of muscle weakness due to antibodies against acetylcholine receptor, [ 13 ] [ 14 ] and its ...
Abnormal muscle fatigue (premature fatigue and/or inability to get into second wind), muscle pain (myalgia), cramping or muscle stiffness during and/or after exercise, [citation needed] Shortness of breath , or rapid breathing , or heavy breathing , or both (exercise hyperventilation) [citation needed]