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Tris(trimethylsilyl)phosphine is prepared by treating trimethylsilyl chloride, white phosphorus, and sodium-potassium alloy: [2] 1/4 P 4 + 3 Me 3 SiCl + 3 K → P(SiMe 3) 3 + 3 KCl. Several other methods exist. [1] Copper phosphide cluster Cu 96 P 30 {P(SiMe 3) 2} 6 (PEt 3) 18 with C and H atoms omitted for clarity (red=Cu, purple=P, tan=Si ...
Many analogues of diethyl phosphite can be prepared. [4] [5] Despite being named as a phosphite the compound exists overwhelmingly in its phosphonate form, (C 2 H 5 O) 2 P(O)H, a property it shares with its parent acid phosphorous acid. Nonetheless many of its reactions appear to proceed via the minor phosphorus(III) tautomer. [6]
Dimethyl methylphosphonate can be prepared from trimethyl phosphite and a halomethane (e.g. iodomethane) via the Michaelis–Arbuzov reaction. [2]Dimethyl methylphosphonate is a schedule 2 chemical as it may be used in the production of chemical weapons.
Bisphosphonates are popular drugs for treatment of osteoporosis. [1] Clodronic acid is a bisphosphonate used as a drug to treat osteoporosis. In biochemistry and medicinal chemistry, phosphonate groups are used as stable bioisosteres for phosphate, such as in the antiviral nucleotide analog, Tenofovir, one of the cornerstones of anti-HIV therapy.
Trimethyl phosphite is an organophosphorus compound with the formula P(OCH 3) 3, often abbreviated P(OMe) 3.It is a colorless liquid with a highly pungent odor. It is the simplest phosphite ester and finds used as a ligand in organometallic chemistry and as a reagent in organic synthesis.
[2] [3] This reaction is widely used for the synthesis of various phosphonates, phosphinates, and phosphine oxides. Several reviews have been published. [4] [5] The reaction also occurs for coordinated phosphite ligands, as illustrated by the demethylation of {(C 5 H 5)Co[(CH 3 O) 3 P] 3} 2+ to give {(C 5 H 5)Co[(CH 3 O) 2 PO] 3} −, which is ...
A trimethylsilyl group (abbreviated TMS) is a functional group in organic chemistry.This group consists of three methyl groups bonded to a silicon atom [−Si(CH 3) 3], which is in turn bonded to the rest of a molecule.
2 Me 3 SiCl + H 2 O → 2 HCl + O[Si(CH 3) 3] 2. It also results from the hydrolysis of silyl ethers and other silyl-protected functional groups. HMDSO can be converted back to the chloride by reaction with Me 2 SiCl 2. [3] Hexamethyldisiloxane is mainly used as source of the trimethylsilyl functional group (-Si(CH 3) 3) in organic synthesis.