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Ketamine. Ketamine (2-CL-2’-oxo-PCM) is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a treatment for depression and in pain management. [19] Ketamine is an NMDA receptor antagonist which accounts for most of its psychoactive effects.
2-Fluorodeschloroketamine. 2-Fluorodeschloroketamine (also known as 2'-Fl-2-Oxo-PCM, Fluoroketamine and 2-FDCK) is a dissociative anesthetic [1] related to ketamine. Its sale and use as a designer drug has been reported in various countries. [2][3][4] It is an analogue of ketamine where the chlorine group has been replaced by fluorine.
Calvin L. Stevens. Calvin Lee Stevens (November 3, 1923 – November 26, 2014) was an American chemist. He was a professor of organic chemistry at Wayne State University, and is known for being the first to synthesize the drug ketamine. [citation needed]
Ketamine can be a lifeline for certain people who have not responded to common treatments for depression, such as medications and different forms of psychotherapy. “(It’s) probably the biggest ...
Ketamine, one of the most popular NMDA receptor antagonists. NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the N -Methyl- D -aspartate receptor (NMDAR). They are commonly used as anesthetics for humans and animals; the state of anesthesia they induce is referred to as dissociative anesthesia.
The finding by the Los Angeles County medical examiner that "Friends" star Matthew Perry died from "acute effects" of ketamine is generating interest in the drug.. Ketamine is generally safe when ...
Norketamine. Norketamine, or N-desmethylketamine, is the major active metabolite of ketamine, which is formed mainly by CYP3A4. [1][2] Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist, [1][3] but is about 3–5 times less potent as an anesthetic in comparison. [2][4]
Hydroxynorketamine (HNK), or 6-hydroxynorketamine, is a minor metabolite of the anesthetic, dissociative, and antidepressant drug ketamine. [1] It is formed by hydroxylation of the intermediate norketamine, another metabolite of ketamine. [1] As of late 2019, (2R,6R)-HNK is in clinical trials for the treatment of depression.