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Vitamin B 12 deficiency can be determined, but not always. [14] This means it measures forms of vitamin B 12 that are "active" and can be used by the body, as well as the "inactive" forms, which cannot. [151] Vitamin B 12 deficiency can be found within normal levels, so clinical symptoms should be taken into account when a diagnosis is made. [2]
Neuropsychiatric symptoms can precede hematological signs and are often the presenting manifestation of the disease. [55] Vitamin B 12 serum levels are used to detect its deficiency, but do not distinguish its causes. Vitamin B 12 levels can be falsely high or low and data for sensitivity and specificity vary widely.
The blind loop syndrome may produce deficiency of vitamin B 12 or folate. Inadequate use of vitamin B 12, which may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia; Pernicious anemia is the most common cause of vitamin B 12 deficiency. [17]
Pernicious anaemia is a lifelong condition that affects nearly 5 in 100,000 people in the UK.
Once you get an evaluation, a doctor will usually order a blood test to check for a vitamin B12 deficiency, along with other potential factors that could cause dementia-like symptoms, Sachdev says.
Over time, a deficiency of B12 can cause problems with balance, confusion, depression, poor memory and possibly dementia, and it can even cause permanent damage to the nervous system, Somers says.
[6] [15] [26] Vitamin B 12 deficiency can also cause symptoms of mania and psychosis. [27] [28] Among other problems, weakened immunity, reduced fertility and interruption of blood circulation in women may occur. [29] The main type of vitamin B12 deficiency anemia is pernicious anemia, [30] characterized by a triad of symptoms:
Vitamin B1 deficiency (thiamine deficiency) was reported to cause seizures, especially in alcoholics. [5] [6] [7] Vitamin B6 depletion (pyridoxine deficiency) was reported to be associated with pyridoxine-dependent seizures. [8] Vitamin B12 deficiency was reported to be the cause of seizures for adults [9] [10] and for infants. [11] [12]
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