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  2. Opioid overdose - Wikipedia

    en.wikipedia.org/wiki/Opioid_overdose

    [13] [14] In 2018, approximately 269 million people had engaged in drug usage at least once, 58 million of which used opioids. [1] Drug use disorders have affected around 35.6 million people worldwide in 2018. [1] The WHO estimates that 70% of deaths due to drug use are in relation to opioids, with 30% being due to overdose. [1]

  3. Opioid - Wikipedia

    en.wikipedia.org/wiki/Opioid

    This requires them to increase their drug dosage to maintain the benefit, and that in turn also increases the unwanted side effects. [78] Long-term opioid use can cause opioid-induced hyperalgesia, which is a condition in which the patient has increased sensitivity to pain. [101] All of the opioids can cause side effects. [70]

  4. Substance use disorder - Wikipedia

    en.wikipedia.org/wiki/Substance_use_disorder

    "Substance use pertains to using select substances such as alcohol, tobacco, illicit drugs, etc. that can cause dependence or harmful side effects."On the other hand, substance abuse is the use of drugs such as prescriptions, over-the-counter medications, or alcohol for purposes other than what they are intended for or using them in excessive ...

  5. Opioid use disorder - Wikipedia

    en.wikipedia.org/wiki/Opioid_use_disorder

    A genetic basis for the efficacy of opioids in the treatment of pain has been demonstrated for several specific variations, but the evidence for clinical differences in opioid effects is not clear. [11] There is an estimated 50% genetic contribution to opioid use disorder.

  6. Opioid-induced hyperalgesia - Wikipedia

    en.wikipedia.org/wiki/Opioid-induced_hyperalgesia

    Opioid-induced hyperalgesia (OIH) or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia, is an uncommon condition of generalized pain caused by the long-term use of high dosages of opioids [1] such as morphine, [2] oxycodone, [3] and methadone. [4] [5] OIH is not necessarily confined to the original affected site. [6]

  7. Fentanyl - Wikipedia

    en.wikipedia.org/wiki/Fentanyl

    Pharmaceutical fentanyl's adverse effects are identical to those of other opioids and narcotics, [17] including addiction, confusion, respiratory depression (which, if extensive and untreated, may lead to respiratory arrest), drowsiness, nausea, visual disturbances, dyskinesia, hallucinations, delirium, a subset of the latter known as "narcotic ...

  8. Analgesic - Wikipedia

    en.wikipedia.org/wiki/Analgesic

    An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management.Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and ...

  9. Prescription drug addiction - Wikipedia

    en.wikipedia.org/wiki/Prescription_Drug_Addiction

    When a chronic prescription drug user suddenly ceases the use of an addictive drug, the person may experience unpleasant withdrawal symptoms depending on the drug type. [24] A constant opioid user may experience withdrawal symptoms such as nausea and diarrhea. [47] Detoxification is a procedure which treats addicts in withdrawal with low doses ...

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