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  2. Transplant rejection - Wikipedia

    en.wikipedia.org/wiki/Transplant_rejection

    Bone marrow transplant can replace the transplant recipient's immune system with the donor's, and the recipient accepts the new organ without rejection. The marrow's hematopoietic stem cells—the reservoir of stem cells replenishing exhausted blood cells including white blood cells forming the immune system—must be of the individual who ...

  3. Hematopoietic stem cell transplantation - Wikipedia

    en.wikipedia.org/wiki/Hematopoietic_stem_cell...

    Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research Center from the 1950s through the 1970s led by E. Donnall Thomas, whose work was later recognized with a Nobel Prize in Physiology or Medicine. Thomas' work showed that bone-marrow cells infused intravenously could ...

  4. Panel-reactive antibody - Wikipedia

    en.wikipedia.org/wiki/Panel-reactive_antibody

    A panel-reactive antibody (PRA) is a group of antibodies in a test serum that are reactive against any of several known specific antigens in a panel of test leukocytes or purified HLA antigens from cells. It is an immunologic metric routinely performed by clinical laboratories on the blood of people awaiting organ transplantation. [1]

  5. Adding stem cells to a kidney transplant could get patients ...

    www.aol.com/news/adding-stem-cells-kidney...

    A novel approach to organ transplantation allowed patients to wean off anti-rejection drugs after two years, according to the results of a phase 3 clinical trial presented Monday.

  6. Stem-cell therapy - Wikipedia

    en.wikipedia.org/wiki/Stem-cell_therapy

    Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.

  7. Donor-specific antibody - Wikipedia

    en.wikipedia.org/wiki/Donor-specific_antibody

    DSA are a result of B cell and plasma cell activation and bind to HLA and/or non-HLA molecules on the endothelium [1] of the graft. They were first described in 1969 by Patel et al., who found that Transplant recipients who were positively tested for DSA using a complement-dependent cytotoxicity crossmatch assay had a higher risk of transplant ...

  8. Immunodeficiency - Wikipedia

    en.wikipedia.org/wiki/Immunodeficiency

    The treatment of primary immunodeficiencies depends on the nature of the defect, and may involve antibody infusions, long-term antibiotics and (in some cases) stem cell transplantation. The characteristics of lacking and/or impaired antibody functions can be related to illnesses such as X-Linked Agammaglobulinemia and Common Variable Immune ...

  9. Peripheral stem cell transplantation - Wikipedia

    en.wikipedia.org/wiki/Peripheral_stem_cell...

    Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", [1] is a method of replacing blood-forming stem cells.Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. [2]

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