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The PICO process (or framework) is a mnemonic used in evidence-based practice (and specifically evidence-based medicine) to frame and answer a clinical or health care related question, [1] though it is also argued that PICO "can be used universally for every scientific endeavour in any discipline with all study designs". [2]
Muriel Skeet, a British nurse, was an early advocate for the development of the evidence base for health care. She produced studies and surveys including Waiting in Outpatients [2] (1965), which received widespread publicity and resulted in the introduction of appointment systems, and Marriage and Nursing [3] (with Gertrude Ramsden, 1967 ...
Keppra (levetiracetam) – an anticonvulsant drug which is sometimes used as a mood stabilizer and has potential benefits for other psychiatric and neurologic conditions such as Tourette syndrome, anxiety disorder, and Alzheimer's disease; Klonopin – anti-anxiety and anti-epileptic medication of the benzodiazepine class
The answer to a research question will help address a research problem or question. [5] Specifying a research question, "the central issue to be resolved by a formal dissertation, thesis, or research project," [6] is typically one of the first steps an investigator takes when undertaking research.
These studies formed the basis for drugs developed by ZZ Biotech, a company co-founded by Zlokovic [217]. The allegations raised significant concerns about the validity of the research and the efficacy of the associated treatments [217]. This narrative is a key component of Charles Piller's book, Doctored, which was published in 2025. [121]
These are lists of investigational drugs: List of investigational analgesics; List of investigational antidepressants; List of investigational antipsychotics; List of investigational anxiolytics; List of investigational attention deficit hyperactivity disorder drugs; List of investigational autism and pervasive developmental disorder drugs
Nicotine – has been associated with improved alertness, attention, memory, and motor performance, according to a meta-analysis. [22] However, a 2020 systematic review raised concerns about potential conflicts of interest, noting industry funding in many studies and inconsistent results regarding nicotine's cognitive effects.
Most clinical studies have been conducted using cannabis cigarettes with a potency of 2-4% THC. However, it is anticipated that there will be requests for cannabis cigarettes with a higher potency or with other mixes of cannabinoids. For example, NIDA has received a request for cigarettes with an 8% potency.