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Chloramphenicol is a broad-spectrum antibiotic that typically stops bacterial growth by stopping the production of proteins. [5] Chloramphenicol was discovered after being isolated from Streptomyces venezuelae in 1947. [8] Its chemical structure was identified and it was first synthesized in 1949.
Since the syndrome is due to the accumulation of chloramphenicol, the signs and symptoms are dose related. [10] According to Kasten's review published in the Mayo Clinic Proceedings, a serum concentration of more than 50 μg/mL is a warning sign, [10] while Hammett-Stabler and John states that the common therapeutics peak level is 10-20 μg/mL and is expected to achieve after 0.5-1.5 hours of ...
The Prescribing Information follows one of two formats: "physician labeling rule" format or "old" (non-PLR) format. For "old" format labeling a "product title" may be listed first and may include the proprietary name (if any), the nonproprietary name, dosage form(s), and other information about the product. The other sections are as follows:
The following other wikis use this file: Usage on ar.wikipedia.org كلورامفينيكول; أمفينيكول; Usage on azb.wikipedia.org کلرامفنیکل
Unlike chloramphenicol, thiamphenicol is not readily metabolized in cattle, poultry, sheep, or humans, but is predominantly excreted unchanged. In pigs and rats the drug is excreted both as parent drug and as thiamphenicol glucuronate. [2] Thiamphenicol can be administered as a part of a complex molecule, Thiamphenicol glycinate acetylcysteine. [4]
Structured Product Labeling (SPL) is a Health Level Seven International (HL7) standard which defines the content of human prescription drug labeling in an XML format. [1] The "drug labeling" includes all published material accompanying a drug, such as the Prescribing Information which contains a great deal of detailed information about the drug.
Doxycycline is given for 7–21 days dependent on the dosage. [11] Tetracycline is effective and administered more frequently, being given for 14–21 days. [11] Other antibiotic choices include enrofloxacin and chloramphenicol. [11] Veterinary-approved flea and tick preparations [12] are recommended, along with other topicals, collars, [13 ...
A drug of last resort (DoLR), also known as a heroic dose, [1] is a pharmaceutical drug which is tried after all other drug options have failed to produce an adequate response in the patient. Drug resistance , such as antimicrobial resistance or antineoplastic resistance , may make the first-line drug ineffective, especially in case of ...