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Clear cell sarcoma is a sub-type of a rare form of cancer called a sarcoma. [1] It is known to occur mainly in the soft tissues and dermis . Rare forms were thought to occur in the gastrointestinal tract before they were discovered to be different and redesignated as gastrointestinal neuroectodermal tumors .
Desmoplastic melanoma, also known as neurotropic melanoma, or spindled melanoma [1] is a rare cutaneous condition characterized by a deeply infiltrating type of melanoma [2]: 696 with an abundance of fibrous matrix. It usually occurs in the head and neck region of older people with sun-damaged skin.
Atypical fibroxanthoma (AFX) of the skin is a low-grade malignancy related to malignant fibrous histiocytoma, which it resembles histologically. [2]: 613 Atypical fibroxanthoma manifests as a hard, pink or red papule or nodule that grows over the course of several months and may bleed or ulcerate.
Spindle cell sarcoma is a type of connective tissue cancer. The tumors generally begin in layers of connective tissue , as found under the skin, between muscles, and surrounding organs, and will generally start as a small, inflamed lump, which grows in size.
In neurobiology, spindle cell refers to: Spindle neuron, also known as a von Economo neuron; In general medicine, a spindle cell may refer to the spindle-shaped cells that are found in certain types of tumor: Inflammatory fibroid polyp; Pigmented spindle cell nevus; Spindle cell carcinoma; Spindle cell lipoma; Spindle cell sarcoma
Mucosal melanoma, also a spindled-cell tumor in many cases, has pleomorphism (more variety in shape/size of tumor cells), intranuclear inclusions, and prominent nucleoli. The neoplastic cells are usually strongly reactive with S100 protein, SOX10, HMB45, Melan-A, and tyrosinase, while negative for SMA or MSA.
Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern.
The primary cause of skin cancer is prolonged exposure to ultraviolet (UV) radiation from the sun or tanning devices. Skin cancer is the most commonly diagnosed form of cancer in humans. [11] [12] [13] There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. [1]