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N,N-Diisopropylethylamine, or Hünig's base, is an organic compound that is a tertiary amine. It is named after the German chemist Siegfried Hünig . It is used in organic chemistry as a non-nucleophilic base. It is commonly abbreviated as DIPEA, DIEA, or i-Pr 2 NEt.
It is also used to prepare N,N-diisopropylethylamine (Hünig's base) by alkylation with diethyl sulfate. [8] The bromide salt of diisopropylamine, diisopropylammonium bromide, is a room-temperature organic ferroelectric material. [9]
A variety of amines and nitrogen heterocycles are useful bases of moderate strength (pK a of conjugate acid around 10-13) . N,N-Diisopropylethylamine (DIPEA, also called Hünig's Base [1]), pK a = 10.75
The molecular formula C 8 H 19 N (molar mass: ... N,N-Diisopropylethylamine, or Hünig's base; Octodrine; Oenethyl This page was last edited on 17 January 2025, at 01 ...
Another non-nucleophilic base is N,N-diisopropylethylamine. Its aqueous p K aH (conjugate acid dissociation constant, a measure of basicity) is 11.07 at 25 °C, [ 1 ] while its p K a (acid dissociation constant, a measure of acidity) is approximately 37.
N,N-Diisopropylaminoethanol (DIPA) is a processor for production of various chemicals and also an intermediate in the production of the nerve agents VX and NX. [ 2 ] It is a colorless liquid, although aged samples can appear yellow.
This page was last edited on 26 May 2006, at 03:19 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply ...
Inspired perhaps by the preliminary research in 1935, independently both groups thought to test whether a medically useful differential toxicity between animals and animal tumors existed. [20] The Yale pharmacologists Louis Goodman and Alfred Gilman were the first to conduct a clinical trial, on 27 August 1942, using the agent HN3 (tris(2 ...