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Anti-centromere antibodies (ACAs; often styled solid, anticentromere) are autoantibodies specific to centromere and kinetochore function. They occur in some autoimmune diseases , frequently in limited systemic scleroderma (formerly called CREST syndrome ), and occasionally in the diffuse form of scleroderma .
1059 12616 Ensembl ENSG00000125817 ENSMUSG00000068267 UniProt P07199 P27790 RefSeq (mRNA) NM_001810 NM_007682 RefSeq (protein) NP_001801 NP_031708 Location (UCSC) Chr 20: 3.78 – 3.79 Mb Chr 2: 131.02 – 131.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans ...
Anti-centromere antibodies are associated with limited cutaneous systemic sclerosis, also known as CREST syndrome, primary biliary cirrhosis and proximal scleroderma. [44] There are six known antigens, which are all associated with the centromere; CENP-A to CENP-F. CENP-A is a 17kDa histone H3-like protein. CENP-B is an 80kDa DNA binding ...
Centromere repositioning and the formation of evolutionary new centromeres has been suggested to be a mechanism of speciation. [39] Centromere proteins are also the autoantigenic target for some anti-nuclear antibodies, such as anti-centromere antibodies.
Anti-La/SS-B autoantibodies: Primary Sjögren syndrome: Anti-centromere antibodies: centromere: CREST syndrome: Anti-dsDNA: double-stranded DNA: SLE: Anti-Jo1: histidine-tRNA ligase: inflammatory myopathy: Anti-RNP: Ribonucleoprotein: Mixed connective tissue disease: Anti-Smith: snRNP core proteins: SLE: Anti-topoisomerase antibodies: Type I ...
Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC conjugate. Anti-SSA autoantibodies (anti–Sjögren's-syndrome-related antigen A autoantibodies, also called anti-Ro, or similar names including anti-SSA/Ro, anti-Ro/SSA, anti–SS-A/Ro, and anti-Ro/SS-A) are a type of anti-nuclear autoantibodies that are associated with ...
A crucial system of ocean currents may already be on course to collapse with devastating implications for sea level rise global weather — leading temperatures to plunge dramatically in some ...
Anti-gp210 antibodies are found in 47% of PBC patients. [28] [29] Anti-centromere antibodies often correlate with developing portal hypertension. [30] Anti-np62 [31] and anti-sp100 are also found in association with PBC. Abdominal ultrasound, magnetic resonance cholangiopancreatography or a CT scan is usually performed to rule out blockage to ...
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