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23936 Ensembl ENSG00000180155 ENSMUSG00000022594 UniProt P0DP57 P0DP58 P0DP60 RefSeq (mRNA) NM_177457 NM_177476 NM_177477 NM_001356370 NM_011838 RefSeq (protein) NP_803253 NP_001343301 NP_076435 NP_001343299 NP_803252 NP_803429 NP_803430 NP_035968 Location (UCSC) Chr 8: 142.77 – 142.78 Mb Chr 15: 74.62 – 74.62 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ly6/neurotoxin 1 is a ...
Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. [1] It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant – alters the normal activity of the nervous system in such a ...
Common examples of neurotoxins include lead, [7] ethanol (drinking alcohol), [8] glutamate, [9] nitric oxide, [10] botulinum toxin (e.g. Botox), [11] tetanus toxin, [12] and tetrodotoxin. [6] Some substances such as nitric oxide and glutamate are in fact essential for proper function of the body and only exert neurotoxic effects at excessive ...
The three-dimensional structure of alpha-bungarotoxin, an alpha-neurotoxin from the venom of Bungarus multicinctus. Gold links indicate disulfide bonds. From 1] α-Neurotoxins are a group of neurotoxic peptides found in the venom of snakes in the families Elapidae and Hydrophiidae. They can cause paralysis, respiratory failure, and death.
Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. [24] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction , thus causing flaccid paralysis . [ 25 ]
Yolk sac progenitor cells require activation colony stimulating factor 1 receptor (CSF1R) for migration into the brain and differentiation into microglia. [36] Additionally, the greatest contribution to microglial repopulation is based upon its local self-renewal, both in steady state and disease, while circulating monocytes may also contribute ...
D 1 receptor has a high degree of structural homology to another dopamine receptor, D 5, and they both bind similar drugs. [13] As a result, none of the known orthosteric ligands is selective for the D 1 vs. the D 5 receptor, but the benzazepines generally are more selective for the D 1 and D 5 receptors versus the D 2-like family. [12]
The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins.