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The endomysium contains a form of transglutaminase called "tissue transglutaminase" or "tTG" for short, and antibodies that bind to this form of transglutaminase are called endomysial autoantibodies (EmA). [6] The antiendomysial antibody test is a histological assay for patient serum binding to esophageal tissue from primate.
Transglutaminase 2 (TG2) is a ubiquitously expressed (intracellular as well as extracellular) protein, with multiple modes of Post-translational regulation, including an allosteric disulfide bond between Cys-370-Cys-371 that renders the enzyme inactive in the extracellular matrix.
Some of these antibodies can recognize only wheat prolamins or very closely related grass seeds; others can detect antigens over broad taxa. The G12 antibody [12] is the newest example which detects the most immunotoxic fragment, a 33-mer peptide from α-2 gliadin; available from Romer Laboratories and the Spanish company Biomedal. It ...
Anti-transglutaminase antibodies are found in celiac disease and may play a role in the small bowel damage in response to dietary gliadin that characterises this condition. [2] In the related condition dermatitis herpetiformis , in which small bowel changes are often found and which responds to dietary exclusion of gliadin-containing wheat ...
ATA antibodies may refer to: Anti-transglutaminase antibodies; Anti-topoisomerase antibodies; Anti-thyroglobulin antibodies This page was last edited on 27 ...
The first anti-glutamate receptor antibody was shown by McNamara JO and colleagues to be directed against the GluR3 subunit of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor. [1] Since then anti-GluR3 antibodies have been demonstrated in temporal lobe epilepsy, epilepsia partialis continua and focal epilepsy. [2]
A deficiency is associated with ichthyosis lamellaris. [11] Epidermal transglutaminase is the autoantigen, in humans, of dermatitis herpetiformis.. A study on the mutation of keratinocyte transglutaminase (TGK) came to conclude that those affected with ichthyosis lamellaris, present a substantial deficit in keratinocyte transglutaminase activity. [8]
In vivo studies of isolated anti-GM1 and GD3 antibodies indicate the antibodies can interfere with motor neuron function. [2] Anti-GD1a antibodies were highly associated acute motor axonal neuropathy while high titers of anti-GM1 were more frequent indicating that GD1a possibly targets the axolemma and nodes of Ranvier [3] most of the Ab+ ...