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However, the reverse transcriptase protein that often comes with the RNA virus can be used as an indirect target for RNA viruses, preventing transcription and synthesis of viral particles. [19] (This is the basis for anti-AIDs and anti-HIV drugs [20])
The term viral protein refers to both the products of the genome of a virus and any host proteins incorporated into the viral particle. Viral proteins are grouped according to their functions, and groups of viral proteins include structural proteins , nonstructural proteins , regulatory proteins , and accessory proteins. [ 1 ]
Viruses force the cell to make new proteins that the cell does not need, but are needed for the virus to reproduce. Protein synthesis consists of two major steps: transcription and translation. [34] Transcription is the process where information in DNA, called the genetic code, is used to produce RNA copies called messenger RNA (mRNA).
Once the viral DNA has taken control it induces the host cell's machinery to synthesize viral DNA and proteins and begins to multiply. [citation needed] The biosynthesis is (e.g. T4) regulated in three phases of mRNA production followed by a phase of protein production. [3] Early phase Enzymes modify the host's transcriptional process by RNA ...
To enter the cells, proteins on the surface of the virus interact with proteins of the cell. Attachment, or adsorption, occurs between the viral particle and the host cell membrane. A hole forms in the cell membrane, then the virus particle or its genetic contents are released into the host cell, where replication of the viral genome may commence.
The viral genome is composed of RNA, which enters the cell through receptor-mediated endocytosis. From there, the RNA acts as a template for complementary RNA synthesis. The complementary strand acts as a template for the production of new viral genomes that are packaged and released from the cell ready to infect more host cells.
Transcription of mRNAs initiated by viral polymerase using cap snatching. The first step of transcription for some negative, single-stranded RNA viruses is cap snatching, in which the first 10 to 20 residues of a host cell RNA are removed (snatched) and used as the 5′ cap and primer to initiate the synthesis of the nascent viral mRNA. [1]
The viral replication, protein synthesis and assembly require a considerable amount of energy, provided by large clusters of mitochondria at the periphery of viroplasms. The virus factory is often enclosed by a membrane derived from the rough endoplasmic reticulum or by cytoskeletal elements .